Investigation of FAS and IL-6 Expression in Placentas with HELLP Syndrome

The aim of our study was to investigate the effect inflammation in placenta on pro-apoptotic development after severe preeclampsia. Placenta tissue samples 15 HELLP syndrome and healthy 35-38th week-pregnant women were involved study. Tissue taken only from maternal side fixed 10 % formaldehyde, then blocked paraffin wax 4-6 mm-thick sections cut stained with Harris Hematoxylene-Eosin. Antigen retrieval performed for sections, incubated FAS antibody anti-IL-6 antibody. After application streptavidin peroxidase followed by AEC chromogen solution, counterstained hematoxylin. Significant thickening fibrinoid layer, degeneration apoptotic change decidua cells, marked increase hyalinized area, degenerative changes syncytial regions chorionic villus an nodes bridges IL- expression observed as positive. positive pycnotic nuclei decidual cells region regions. It that proapoptotic process increased a result concluded control cytokine activity reduction signal during will slow down syndrome.